Laurent Lagrost Selected Research

Phospholipid Transfer Proteins

1/2022	New therapeutic horizons for plasma phospholipid transfer protein (PLTP): Targeting endotoxemia, infection and sepsis.
1/2021	Intra-Abdominal Lipopolysaccharide Clearance and Inactivation in Peritonitis: Key Roles for Lipoproteins and the Phospholipid Transfer Protein.
4/2018	Deletion of plasma Phospholipid Transfer Protein (PLTP) increases microglial phagocytosis and reduces cerebral amyloid-β deposition in the J20 mouse model of Alzheimer's disease.
1/2018	PhosphoLipid transfer protein (PLTP) exerts a direct pro-inflammatory effect on rheumatoid arthritis (RA) fibroblasts-like-synoviocytes (FLS) independently of its lipid transfer activity.
1/2017	Recombinant human plasma phospholipid transfer protein (PLTP) to prevent bacterial growth and to treat sepsis.
11/2016	Plasma phospholipid transfer protein (PLTP) modulates adaptive immune functions through alternation of T helper cell polarization.
9/2013	Development of abdominal aortic aneurysm is decreased in mice with plasma phospholipid transfer protein deficiency.
4/2013	Increased amyloid-β peptide-induced memory deficits in phospholipid transfer protein (PLTP) gene knockout mice.
4/2011	Worsening of diet-induced atherosclerosis in a new model of transgenic rabbit expressing the human plasma phospholipid transfer protein.
7/2008	Effect of plasma phospholipid transfer protein deficiency on lethal endotoxemia in mice.

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Laurent Lagrost Research Topics

Disease

24	Inflammation (Inflammations) 01/2022 - 07/2008
22	Atherosclerosis 01/2021 - 09/2003
8	Endotoxemia 01/2022 - 07/2008
7	Neoplasms (Cancer) 12/2020 - 02/2010
6	Sepsis (Septicemia) 01/2022 - 05/2014
6	Type 2 Diabetes Mellitus (MODY) 12/2015 - 06/2009
5	Atherosclerotic Plaque (Atheroma) 01/2021 - 06/2015
4	Obesity 01/2019 - 03/2014
4	Cardiovascular Diseases (Cardiovascular Disease) 01/2017 - 02/2012
3	Infections 01/2022 - 01/2019
3	Thrombosis (Thrombus) 11/2021 - 09/2006
3	Coinfection 01/2021 - 01/2017
3	Dyslipidemias (Dyslipidemia) 01/2017 - 06/2012
3	Hypercholesterolemia 04/2012 - 06/2003
2	Graft vs Host Disease (Graft-Versus-Host Disease) 01/2022 - 01/2017
2	Carcinogenesis 01/2022 - 12/2013
2	Peritonitis 01/2021 - 01/2021
2	Hypoxia (Hypoxemia) 01/2021 - 01/2020
2	Chronic Kidney Failure (Chronic Renal Failure) 01/2021 - 01/2019
2	Septic Shock (Toxic Shock Syndrome) 12/2020 - 12/2015
2	Colitis 10/2020 - 05/2020
2	Alzheimer Disease (Alzheimer's Disease) 04/2018 - 04/2013
2	Diabetes Mellitus 12/2015 - 10/2012
1	Cholangitis 01/2022
1	Bacterial Infections (Bacterial Infection) 01/2022
1	Stroke (Strokes) 11/2021
1	Thromboembolism 11/2021
1	COVID-19 01/2021
1	Pneumonia (Pneumonitis) 01/2021
1	Acute-Phase Reaction 01/2021
1	Shock 01/2021
1	Colorectal Neoplasms (Colorectal Cancer) 12/2020
1	Bacteremia 12/2020
1	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 12/2020
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 10/2020
1	Fibrosis (Cirrhosis) 10/2020

Drug/Important Bio-Agent (IBA)

23	Lipoproteins (Lipoprotein)IBA 01/2022 - 05/2003
19	LipidsIBA 01/2022 - 05/2003
17	CholesterolIBA 01/2022 - 07/2006
13	LipopolysaccharidesIBA 11/2021 - 02/2014
12	Phospholipid Transfer ProteinsIBA 01/2022 - 06/2006
6	OxysterolsIBA 01/2021 - 01/2012
6	Cholesterol Ester Transfer ProteinsIBA 01/2021 - 05/2003
6	Liver X ReceptorsIBA 01/2020 - 01/2012
6	Proteins (Proteins, Gene)FDA Link 01/2019 - 06/2006
5	CytokinesIBA 01/2021 - 04/2012
5	Fatty Acids (Saturated Fatty Acids)IBA 01/2021 - 03/2015
5	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2018 - 10/2011
5	Vitamin E FDA LinkGeneric 01/2018 - 09/2003
5	AntioxidantsIBA 04/2013 - 11/2002
4	HDL LipoproteinsIBA 01/2022 - 11/2007
4	Apolipoprotein C-I (Apolipoprotein C1)IBA 01/2021 - 06/2012
4	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 02/2014
4	LDL Lipoproteins (beta Lipoproteins)IBA 12/2020 - 01/2005
4	oxidized low density lipoproteinIBA 12/2020 - 09/2006
3	Biological ProductsIBA 11/2021 - 06/2006
3	ApolipoproteinsIBA 01/2021 - 10/2011
3	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2021 - 12/2013
3	HDL CholesterolIBA 01/2021 - 09/2003
3	Biomarkers (Surrogate Marker)IBA 01/2019 - 04/2013
3	Apolipoproteins B (ApoB)IBA 10/2017 - 09/2003
3	Apolipoprotein A-I (Apolipoprotein A1)IBA 02/2011 - 04/2009
2	Triglycerides (Triacylglycerol)IBA 01/2022 - 10/2019
2	EnzymesIBA 01/2022 - 04/2018
2	Lipopolysaccharide ReceptorsIBA 01/2021 - 01/2019
2	C-Reactive ProteinIBA 01/2021 - 10/2012
2	LDL Receptors (LDL Receptor)IBA 01/2021 - 10/2011
2	Nonesterified Fatty Acids (NEFA)IBA 01/2021 - 03/2015
2	EndotoxinsIBA 01/2021 - 04/2019
2	Anti-Bacterial Agents (Antibiotics)IBA 12/2020 - 01/2019
2	Dextrans (Dextran)FDA Link 10/2020 - 10/2017
2	sodium sulfate (sodium bisulfate)FDA LinkGeneric 10/2020 - 10/2017
2	OxidesIBA 01/2019 - 04/2012
2	Amyloid (Amyloid Fibrils)IBA 04/2018 - 04/2013
2	Phospholipids (Phosphatides)FDA LinkGeneric 01/2018 - 09/2003
2	Glucagon-Like Peptide 1 (GLP 1)IBA 10/2017 - 02/2014
2	Arachidonic Acid (Vitamin F)IBA 01/2016 - 06/2015
2	Insulin (Novolin)FDA Link 12/2015 - 03/2014
2	AcidsIBA 12/2013 - 01/2011
2	Peptides (Polypeptides)IBA 04/2013 - 01/2011
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 10/2012 - 06/2009
2	Peroxynitrous Acid (Peroxynitrite)IBA 09/2011 - 02/2010
2	CopperIBA 01/2005 - 09/2003
1	InterferonsIBA 01/2022
1	CarbonIBA 01/2021
1	HexokinaseIBA 01/2021
1	human APOC1 proteinIBA 01/2021
1	Arachidonic AcidsIBA 01/2021
1	Cisplatin (Platino)FDA LinkGeneric 12/2020
1	NF-kappa B (NF-kB)IBA 10/2020
1	InterleukinsIBA 10/2020
1	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 10/2020
1	Folic Acid (Vitamin M)FDA LinkGeneric 10/2020

Therapy/Procedure

5	Therapeutics 12/2020 - 01/2011
3	Immunotherapy 01/2019 - 02/2010
3	Transplantation 01/2019 - 01/2018
2	Ligation 01/2021 - 11/2020
2	Punctures 01/2021 - 11/2020
1	Cell Transplantation 01/2022
1	Blood Component Removal (Apheresis) 12/2020